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Comparative genomics of Vitis vinifera and Muscadinia rotundifolia for the study of disease resistance in the Vitaceae


ANR funded project ANR-08-GENM-007, with the support of CNIV (Comité National des Interprofessions des Vins d'appellation d'origine)


Muscadinia rotundifolia is closely related to Vitis and it is a source of resistance to several pathogens that is currently being used as a genitor in breeding programmes at INRA.
 The main goal of this project is to take advantage of the existence of the grapevine genome sequence to accelerate the functional characterization of the resistance to several grapevine pathogens found in M. rotundifolia. To achieve this goal, a step of development of resources for the analysis and exploitation of the syntheny between V. vinifera and M. rotundifolia is required.

 The stages of the project are:


  •  Development of markers for genetic mapping in M. rotundifolia.
  •  Genetic mapping in M. rotundifolia and development of a comparative genomic map with V. vinifera. Comparing both genetic maps will unveil the degree of syntheny existing between both species and reveal the position of the clusters of resistance genes in M. rotundifolia.
  •  Study of microsyntheny between M. rotundifolia and V. vinifera in two regions involved into disease resistance and study of the mechanisms of introgression. This research will result in a better understanding of the suppression of genetic recombination found in some hybrids Vitis x Muscadinia.
  •  Constitution of a collection of M. rotundifolia NBS-LRR resistance genes and preliminary testing of candidate genes. Anchoring a M. rotundifolia BAC library to the grapevine reference genome sequence using the BES, assisted by comparative mapping, will result in the identification of M. rotundifolia BAC clones containing resistance genes. The sequencing of some of these BAC clones will allow the identification of candidate genes.


Duration: 01/01/2009 to 31/12/2011

Coordinator: Dr. Pedro F. Mestre


Laboratories Address Person Links
logo INRAE UMR 1131 INRA / UDS Santé de la Vigne et Qualité du Vin
28, rue de Herrlisheim, BP 507
68021 Colmar cedex France


Dr. Pedro F. Mestre

Santé de la Vigne et Qualité du Vin

UMR INRA CNRS Université d’Evry Génomique Végétale
 2 rue Gaston Crémieux, BP 5008

 F-91057 Evry cedex France

Dr. Anne-Françoise Adam-Blondon Grapevine and Forest Trees Genomics
Logo_URGI URGI INRA de Versailles
 Route de Saint-Cyr
 F-78000 Versailles, France
Dr. Nathalie Choisne Unité de Recherche en Génomique Info
 2 rue Gaston Crémieux, CP 57021
 F-91057 Evry Cedex, France
Dr. Dominique Brunel Etude du Polymorphisme des Génomes Végétaux
Plate-Forme de cytogénétique Moléculaire DGAP
 UMR 118 "Amélioration des Plantes et Biotechnologie Végétal"
 Domaine de la Motte, BP 35327
 35653 Le Rheu cedex, France
Dr. Olivier Coriton Plate-Forme de cytogénétique moléculaire


  • Access to private data with GBrowse (grapevine genome 12X version with Muscares data)
  • Dataset comprising the resequencing raw data
    • DOI: 10.15454/1.5009976984187844E12
    • Download link (restricted access): here
    • Described in  GnpSeqNGS (NGS project description)
    • Available soon in EMBL
  • Quality control & Cleaning process for Illumina GAII runs :





URGI shared area MUSCARES directory with Alfresco Registered access

To share documents with other MUSCARES project members, use Alfresco, our web software of electronic documents management .

To access to the Alfresco tool :

  • the first form is the secured web server authentification with the URGI login/password.
  • the 2nd form is Alfresco authentification with the Alfresco login/password.

The MUSCARES directory path is Compagny Home > Projects > Muscares.
 To ask for an account on the URGI secure server, please complete the form
 To ask for an account on the Alfresco tool, please contact us



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Update: 03 Aug 2017
Creation date: 01 Apr 2010