Study : Sexual-lineage-specific DNA methylation regulates meiosis in Arabidopsis

Identification

Name
Sexual-lineage-specific DNA methylation regulates meiosis in Arabidopsis
Identifier
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Source
EBI European Nucleotide Archive logo
Data link
Link to this study on EBI European Nucleotide Archive
Description
We report a distinctive gene-targeted RNA-directed DNA methylation (RdDM) activity in the Arabidopsis thaliana male sexual lineage that regulates gene expression in meiocytes. Loss of sexual-lineage-specific RdDM causes mis-splicing of the MPS1 gene (also known as PRD2), thereby disrupting meiosis. Our results establish a regulatory paradigm in which de novo methylation creates a cell-lineage-specific epigenetic signature that controls gene expression and contributes to cellular function in flowering plants. Overall design: Whole genome bisulfite sequencing and RNA-seq of wild type and RdDM mutant arabidopsis male sex cells and somatic tissues
Data files

Genotype

Accession number Name Taxon