Protein : Qrob_P0614140.2 Q. robur
Protein Identifier  ? Qrob_P0614140.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) K14724 - solute carrier family 9 (sodium/hydrogen exchanger), member 8 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 526  
Kegg Orthology  K14724
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0 Synonyms

11 GO Terms

Identifier Name Description
GO:0055085 transmembrane transport The process in which a solute is transported from one side of a membrane to the other.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0015299 solute:proton antiporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
GO:0015385 sodium:proton antiporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
GO:0005774 vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0009651 response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
GO:0055075 potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.

26 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_026524 1 525 + 525 Gaps:24 99.63 547 74.13 0.0 Sodium/hydrogen exchanger 1
blastp_kegg lcl|vvi:100264772 1 524 + 524 Gaps:25 100.00 541 73.75 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|fve:101304782 1 521 + 521 Gaps:33 95.51 557 75.38 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|pmum:103344682 1 521 + 521 Gaps:26 98.90 543 76.54 0.0 sodium/hydrogen exchanger 1-like
blastp_kegg lcl|pop:POPTR_0013s02760g 1 525 + 525 Gaps:30 99.81 538 73.56 0.0 hypothetical protein
blastp_kegg lcl|rcu:RCOM_1430330 19 521 + 503 Gaps:27 73.34 709 73.65 0.0 sodium/hydrogen exchanger putative
blastp_kegg lcl|pper:PRUPE_ppa003873mg 1 521 + 521 Gaps:26 98.90 543 75.98 0.0 hypothetical protein
blastp_kegg lcl|mdm:103413962 1 525 + 525 Gaps:27 96.10 564 75.28 0.0 sodium/hydrogen exchanger 1-like
blastp_kegg lcl|mdm:103450961 1 525 + 525 Gaps:27 96.10 564 75.28 0.0 sodium/hydrogen exchanger 1-like
blastp_kegg lcl|mdm:103433979 1 525 + 525 Gaps:34 86.09 640 73.14 0.0 sodium/hydrogen exchanger 1-like
blastp_uniprot_sprot sp|Q56XP4|NHX2_ARATH 10 517 + 508 Gaps:44 96.34 546 60.65 0.0 Sodium/hydrogen exchanger 2 OS Arabidopsis thaliana GN NHX2 PE 2 SV 2
blastp_uniprot_sprot sp|Q68KI4|NHX1_ARATH 10 525 + 516 Gaps:30 98.88 538 60.71 0.0 Sodium/hydrogen exchanger 1 OS Arabidopsis thaliana GN NHX1 PE 1 SV 2
blastp_uniprot_sprot sp|Q84WG1|NHX3_ARATH 21 488 + 468 Gaps:23 96.42 503 57.11 0.0 Sodium/hydrogen exchanger 3 OS Arabidopsis thaliana GN NHX3 PE 2 SV 2
blastp_uniprot_sprot sp|Q8S397|NHX4_ARATH 25 505 + 481 Gaps:30 94.71 529 54.09 3e-177 Sodium/hydrogen exchanger 4 OS Arabidopsis thaliana GN NHX4 PE 2 SV 2
blastp_uniprot_sprot sp|Q9Y2E8|SL9A8_HUMAN 27 506 + 480 Gaps:88 83.30 581 33.06 7e-56 Sodium/hydrogen exchanger 8 OS Homo sapiens GN SLC9A8 PE 1 SV 4
blastp_uniprot_sprot sp|Q5ZJ75|SL9A8_CHICK 27 444 + 418 Gaps:63 75.09 574 34.34 5e-55 Sodium/hydrogen exchanger 8 OS Gallus gallus PE 2 SV 1
blastp_uniprot_sprot sp|Q4L208|SL9A8_RAT 27 506 + 480 Gaps:92 84.17 575 33.47 1e-54 Sodium/hydrogen exchanger 8 OS Rattus norvegicus GN Slc9a8 PE 2 SV 1
blastp_uniprot_sprot sp|Q8R4D1|SL9A8_MOUSE 27 506 + 480 Gaps:92 84.03 576 33.26 2e-54 Sodium/hydrogen exchanger 8 OS Mus musculus GN Slc9a8 PE 2 SV 1
blastp_uniprot_sprot sp|Q552S0|NHE1_DICDI 53 506 + 454 Gaps:82 62.31 674 33.81 1e-43 Sodium/hydrogen exchanger 1 OS Dictyostelium discoideum GN nhe1 PE 2 SV 1
blastp_uniprot_sprot sp|Q8RWU6|NHX6_ARATH 34 462 + 429 Gaps:61 81.50 535 32.34 7e-42 Sodium/hydrogen exchanger 6 OS Arabidopsis thaliana GN NHX6 PE 1 SV 3
rpsblast_cdd gnl|CDD|162063 53 467 + 415 Gaps:50 74.60 559 28.06 1e-44 TIGR00840 b_cpa1 sodium/hydrogen exchanger 3. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria blue green bacteria yeast plants and animals.Transporters from eukaryotes have been functionally characterized and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation extruding the H+ generated during metabolism and (2) salt tolerance (in plants) due to Na+ uptake into vacuoles.This Hmm is specific for the eukaryotic members members of this family.
rpsblast_cdd gnl|CDD|201544 85 418 + 334 Gaps:52 85.95 370 27.04 3e-24 pfam00999 Na_H_Exchanger Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
rpsblast_cdd gnl|CDD|30375 53 427 + 375 Gaps:37 86.71 429 22.04 3e-22 COG0025 NhaP NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|129911 82 419 + 338 Gaps:50 67.05 525 24.72 6e-16 TIGR00831 a_cpa1 Na+/H+ antiporter bacterial form. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria blue green bacteria yeast plants and animals. Transporters from eukaryotes have been functionally characterized and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation extruding the H+ generated during metabolism and (2) salt tolerance (in plants) due to Na+ uptake into vacuoles. This Hmm is specific for the bacterial members of this family.
rpsblast_kog gnl|CDD|37176 7 517 + 511 Gaps:60 94.78 575 40.00 1e-115 KOG1965 KOG1965 KOG1965 Sodium/hydrogen exchanger protein [Inorganic ion transport and metabolism].
rpsblast_kog gnl|CDD|37177 21 427 + 407 Gaps:52 61.04 670 26.16 7e-40 KOG1966 KOG1966 KOG1966 Sodium/hydrogen exchanger protein [Inorganic ion transport and metabolism].

29 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 86 103 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 115 138 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 289 306 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 326 348 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 25 45 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 250 269 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 104 114 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 46 56 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 75 85 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 270 288 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 158 180 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 1 506 506 PTHR10110:SF101 none none IPR029872
Phobius 1 24 24 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 139 157 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 307 325 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 401 422 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 423 525 103 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Pfam 28 427 400 PF00999 none Sodium/hydrogen exchanger family IPR006153
PANTHER 1 506 506 PTHR10110 "Reactome:REACT_15518";signature_desc=SODIUM/HYDROGEN EXCHANGER none IPR018422
Phobius 387 400 14 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 223 249 27 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 349 367 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 181 199 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 57 74 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 200 222 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PRINTS 86 97 12 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
PRINTS 115 123 9 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
PRINTS 100 114 15 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
Phobius 368 386 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none

11 Localization

Analysis Start End Length
TMHMM 115 137 22
TMHMM 284 306 22
TMHMM 249 271 22
TMHMM 400 422 22
TMHMM 54 71 17
TMHMM 157 179 22
TMHMM 86 103 17
TMHMM 200 222 22
TMHMM 326 348 22
TMHMM 368 390 22
TMHMM 23 45 22

6 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran_2000_2002_QTL6_Delta.F Qrob_Chr03 3 s_2HYXJ2_207 s_1AUAXK_317 29.12 6,3 45,37 lod 3.1666 0.026
Bourran2_2014_nLBD_3P Qrob_Chr03 3 s_1ET7H8_604 s_1BYNB5_834 23,73 0 46,72 lod 1,7573 3,8
PM_1999_QTL14_peak_Bud_burst_3P Qrob_Chr03 3 s_2F0SI1_756 v_6056_735 11,78 3,78 50,78 lod 2,5 4,5
Bourran2_2014_rEpiBC*_3P Qrob_Chr03 3 s_1A3B3X_1163 s_1DKGMO_450 23,04 4,92 41,12 lod 2,5668 7

0 Targeting