Protein : Qrob_P0563410.2 Q. robur
Protein Identifier  ? Qrob_P0563410.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=7) K01530 - phospholipid-translocating ATPase [EC:3.6.3.1] Code Enzyme  EC:3.6.3.1
Gene Prediction Quality  validated Protein length 

Sequence

Length: 1192  
Kegg Orthology  K01530
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0 Synonyms

7 GO Terms

Identifier Name Description
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0046872 metal ion binding Interacting selectively and non-covalently with any metal ion.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0000166 nucleotide binding Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
GO:0000287 magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
GO:0004012 phospholipid-translocating ATPase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.
GO:0015914 phospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.

39 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0012s05450g 1 1186 + 1186 Gaps:4 99.50 1196 76.97 0.0 POPTRDRAFT_421641 hypothetical protein
blastp_kegg lcl|vvi:100247431 1 1177 + 1177 Gaps:4 99.08 1192 77.39 0.0 putative phospholipid-transporting ATPase 9-like
blastp_kegg lcl|cit:102622947 1 1182 + 1182 Gaps:7 99.16 1189 77.78 0.0 putative phospholipid-transporting ATPase 9-like
blastp_kegg lcl|pper:PRUPE_ppa000418mg 1 1189 + 1189 Gaps:7 99.83 1198 75.25 0.0 hypothetical protein
blastp_kegg lcl|mdm:103437960 4 1191 + 1188 Gaps:7 99.66 1193 74.94 0.0 putative phospholipid-transporting ATPase 9
blastp_kegg lcl|mdm:103455466 17 1191 + 1175 Gaps:5 98.49 1192 75.04 0.0 putative phospholipid-transporting ATPase 9
blastp_kegg lcl|pxb:103930036 17 1191 + 1175 Gaps:5 98.49 1192 75.55 0.0 putative phospholipid-transporting ATPase 9
blastp_kegg lcl|gmx:100797039 1 1180 + 1180 Gaps:6 99.07 1189 74.87 0.0 putative phospholipid-transporting ATPase 9-like
blastp_kegg lcl|pvu:PHAVU_009G201600g 6 1191 + 1186 Gaps:6 99.41 1195 73.74 0.0 hypothetical protein
blastp_kegg lcl|pxb:103938323 4 1191 + 1188 Gaps:6 99.66 1194 74.29 0.0 putative phospholipid-transporting ATPase 9
blastp_pdb 3a3y_A 577 927 + 351 Gaps:72 30.45 1028 29.07 2e-10 mol:protein length:1028 Na K-ATPase alpha subunit
blastp_pdb 2zxe_A 577 927 + 351 Gaps:72 30.45 1028 29.07 2e-10 mol:protein length:1028 Na K-ATPase alpha subunit
blastp_uniprot_sprot sp|Q9SX33|ALA9_ARATH 9 1189 + 1181 Gaps:10 98.75 1200 67.85 0.0 Putative phospholipid-transporting ATPase 9 OS Arabidopsis thaliana GN ALA9 PE 3 SV 1
blastp_uniprot_sprot sp|Q9LI83|ALA10_ARATH 9 1184 + 1176 Gaps:10 98.00 1202 67.23 0.0 Phospholipid-transporting ATPase 10 OS Arabidopsis thaliana GN ALA10 PE 1 SV 1
blastp_uniprot_sprot sp|Q9SAF5|ALA11_ARATH 1 1184 + 1184 Gaps:13 98.84 1203 66.61 0.0 Putative phospholipid-transporting ATPase 11 OS Arabidopsis thaliana GN ALA11 PE 2 SV 1
blastp_uniprot_sprot sp|P57792|ALA12_ARATH 2 1171 + 1170 Gaps:5 98.90 1184 66.10 0.0 Putative phospholipid-transporting ATPase 12 OS Arabidopsis thaliana GN ALA12 PE 2 SV 1
blastp_uniprot_sprot sp|Q9LK90|ALA8_ARATH 1 1143 + 1143 Gaps:12 96.47 1189 63.12 0.0 Putative phospholipid-transporting ATPase 8 OS Arabidopsis thaliana GN ALA8 PE 3 SV 1
blastp_uniprot_sprot sp|Q9LNQ4|ALA4_ARATH 1 1185 + 1185 Gaps:46 98.60 1216 55.80 0.0 Putative phospholipid-transporting ATPase 4 OS Arabidopsis thaliana GN ALA4 PE 1 SV 2
blastp_uniprot_sprot sp|Q9SGG3|ALA5_ARATH 1 1185 + 1185 Gaps:48 98.62 1228 55.24 0.0 Putative phospholipid-transporting ATPase 5 OS Arabidopsis thaliana GN ALA5 PE 3 SV 1
blastp_uniprot_sprot sp|Q9LVK9|ALA7_ARATH 8 1179 + 1172 Gaps:58 96.06 1243 55.86 0.0 Putative phospholipid-transporting ATPase 7 OS Arabidopsis thaliana GN ALA7 PE 3 SV 3
blastp_uniprot_sprot sp|Q9SLK6|ALA6_ARATH 8 1179 + 1172 Gaps:50 96.45 1240 54.35 0.0 Phospholipid-transporting ATPase 6 OS Arabidopsis thaliana GN ALA6 PE 1 SV 2
blastp_uniprot_sprot sp|Q9XIE6|ALA3_ARATH 38 1168 + 1131 Gaps:33 92.00 1213 47.13 0.0 Phospholipid-transporting ATPase 3 OS Arabidopsis thaliana GN ALA3 PE 1 SV 2
rpsblast_cdd gnl|CDD|200120 53 1144 + 1092 Gaps:42 99.91 1057 50.85 0.0 TIGR01652 ATPase-Plipid phospholipid-translocating P-type ATPase flippase. This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.
rpsblast_cdd gnl|CDD|178732 37 1156 + 1120 Gaps:78 92.87 1178 37.20 0.0 PLN03190 PLN03190 aminophospholipid translocase Provisional.
rpsblast_cdd gnl|CDD|30822 48 1120 + 1073 Gaps:269 92.69 917 29.29 1e-112 COG0474 MgtA Cation transport ATPase [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|211660 102 771 + 670 Gaps:165 82.01 528 33.95 7e-42 TIGR01494 ATPase_P-type ATPase P-type (transporting) HAD superfamily subfamily IC. The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway however in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497 IB (heavy metals) TIGR01525 IIA1 (SERCA-type Ca++) TIGR01116 IIA2 (PMR1-type Ca++) TIGR01522 IIB (PMCA-type Ca++) TIGR01517 IIC (Na+/K+ H+/K+ antiporters) TIGR01106 IID (fungal-type Na+ and K+) TIGR01523 IIIA (H+) TIGR01647 IIIB (Mg++) TIGR01524 IV (phospholipid flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493 TIGR01509 TIGR01549 TIGR01544 and TIGR01545). Based on these classifications the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.
rpsblast_cdd gnl|CDD|162469 416 883 + 468 Gaps:104 36.62 1054 27.98 2e-26 TIGR01657 P-ATPase-V P-type ATPase of unknown pump specificity (type V). These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.
rpsblast_cdd gnl|CDD|200073 400 970 + 571 Gaps:125 51.69 917 29.32 5e-17 TIGR01116 ATPase-IIA1_Ca sarco/endoplasmic reticulum calcium-translocating P-type ATPase. This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice at least there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types SERCA and PMR1 the latter of which is modelled by TIGR01522.
rpsblast_cdd gnl|CDD|130585 71 878 + 808 Gaps:275 66.86 884 28.26 5e-16 TIGR01522 ATPase-IIA2_Ca golgi membrane calcium-translocating P-type ATPase. This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types SERCA and PMR1 the former of which is modelled by TIGR01116.
rpsblast_cdd gnl|CDD|188151 558 746 + 189 Gaps:38 18.75 944 29.94 5e-16 TIGR01517 ATPase-IIB_Ca plasma-membrane calcium-translocating P-type ATPase. This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes out of the cell. In some organisms this type of pump may also be found in vacuolar membranes. In humans and mice at least there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly there are no human diseases linked to PMCA defects although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are modelled by two corresponding families (TIGR01116 and TIGR01522). This model is well separated from those.

45 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SUPERFAMILY 494 698 205 SSF81660 none none IPR023299
Phobius 80 96 17 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
SUPERFAMILY 242 282 41 SSF81653 none none none
SUPERFAMILY 135 207 73 SSF81653 none none none
Gene3D 412 463 52 G3DSA:3.40.1110.10 none none IPR023299
Gene3D 505 702 198 G3DSA:3.40.1110.10 none none IPR023299
ProSitePatterns 424 430 7 PS00154 none E1-E2 ATPases phosphorylation site. IPR018303
PRINTS 422 436 15 PR00119 none P-type cation-transporting ATPase superfamily signature IPR001757
PRINTS 859 878 20 PR00119 none P-type cation-transporting ATPase superfamily signature IPR001757
Pfam 421 870 450 PF12710 none haloacid dehalogenase-like hydrolase none
Phobius 1089 1107 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 353 376 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 300 319 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 1 79 79 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 6 1185 1180 PTHR24092 none none IPR006539
Gene3D 81 209 129 G3DSA:2.70.150.10 none none IPR008250
Gene3D 247 283 37 G3DSA:2.70.150.10 none none IPR008250
Phobius 122 299 178 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
SUPERFAMILY 833 903 71 SSF56784 none none IPR023214
SUPERFAMILY 646 752 107 SSF56784 none none IPR023214
SUPERFAMILY 410 434 25 SSF56784 none none IPR023214
Phobius 922 939 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Pfam 108 385 278 PF00122 none E1-E2 ATPase IPR008250
Phobius 1108 1126 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 320 352 33 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 1063 1068 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
SUPERFAMILY 284 416 133 SSF81665 none none none
SUPERFAMILY 48 139 92 SSF81665 none none none
SUPERFAMILY 908 1136 229 SSF81665 none none none
Gene3D 830 916 87 G3DSA:3.40.50.1000 none none IPR023214

8 Localization

Analysis Start End Length
TMHMM 356 378 22
TMHMM 1039 1061 22
TMHMM 1068 1087 19
TMHMM 300 322 22
TMHMM 952 971 19
TMHMM 1002 1024 22
TMHMM 1107 1129 22
TMHMM 920 942 22

6 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL5_peak_Bud_burst_A4 Qrob_Chr10 10 s_1C8OKQ_688 v_12844_707 25,6 13,9 39,9 lod 2,7 6,1
Bourran2_2002_QTL13_peak_Bud_burst_3P Qrob_Chr10 10 s_1B1AG7_637 s_1A3A1N_709 19,44 0 49,44 lod 3 5,6
Bourran2_2002_QTL15_peak_Bud_burst_A4 Qrob_Chr10 10 v_7579_71 s_1ATZMJ_189 23,94 0 43,64 lod 3,7 5,4
Bourran2_2014_vSeqBC_A4 Qrob_Chr10 10 s_1BAM4E_1326 s_1C0HD0_1012 36,88 7,71 46,03 lod 2,6164 7,3
Champenoux_2015_nPriLBD_3P Qrob_Chr10 10 v_15000_157 v_15000_310 15,68 15,9 15,91 lod 2.4 5.5
PM_1999_QTL16_peak_Bud_burst_3P Qrob_Chr10 10 s_1B6YNI_505 s_1A1ZO_1322 7,48 0 31,48 lod 4 7,1

0 Targeting