Protein : Qrob_P0349670.2 Q. robur
Protein Identifier  ? Qrob_P0349670.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) PTHR24092:SF7 - SIMILAR TO ATPASE, CLASS II, TYPE 9A (FRAGMENT) Code Enzyme  EC:3.6.3.1
Gene Prediction Quality  validated Protein length 

Sequence

Length: 1223  
Kegg Orthology  K14802
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0 Synonyms

7 GO Terms

Identifier Name Description
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0046872 metal ion binding Interacting selectively and non-covalently with any metal ion.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0000166 nucleotide binding Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
GO:0000287 magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
GO:0004012 phospholipid-translocating ATPase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.
GO:0015914 phospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.

34 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa000382mg 1 1222 + 1222 Gaps:8 100.00 1224 80.88 0.0 hypothetical protein
blastp_kegg lcl|pmum:103330971 1 1222 + 1222 Gaps:8 100.00 1224 79.90 0.0 phospholipid-transporting ATPase 1
blastp_kegg lcl|mdm:103420527 1 1222 + 1222 Gaps:7 100.00 1225 78.61 0.0 phospholipid-transporting ATPase 1-like
blastp_kegg lcl|tcc:TCM_044500 42 1222 + 1181 Gaps:7 96.72 1220 81.53 0.0 Aminophospholipid ATPase isoform 1
blastp_kegg lcl|rcu:RCOM_0943250 1 1222 + 1222 Gaps:10 100.00 1226 79.36 0.0 phospholipid-transporting atpase putative (EC:3.6.3.1)
blastp_kegg lcl|cic:CICLE_v10014078mg 80 1222 + 1143 Gaps:6 97.04 1184 81.81 0.0 hypothetical protein
blastp_kegg lcl|cit:102621803 80 1222 + 1143 Gaps:6 97.04 1184 81.81 0.0 phospholipid-transporting ATPase 1-like
blastp_kegg lcl|pxb:103946114 1 1222 + 1222 Gaps:42 100.00 1260 76.90 0.0 phospholipid-transporting ATPase 1
blastp_kegg lcl|vvi:100254060 1 1222 + 1222 Gaps:5 100.00 1227 75.79 0.0 phospholipid-transporting ATPase 1-like
blastp_kegg lcl|mdm:103428426 43 1222 + 1180 Gaps:7 100.00 1183 79.21 0.0 phospholipid-transporting ATPase 1-like
blastp_uniprot_sprot sp|P98204|ALA1_ARATH 84 1222 + 1139 Gaps:19 97.41 1158 73.85 0.0 Phospholipid-transporting ATPase 1 OS Arabidopsis thaliana GN ALA1 PE 1 SV 1
blastp_uniprot_sprot sp|O94296|YOOC_SCHPO 28 1200 + 1173 Gaps:85 91.73 1258 39.08 0.0 Probable phospholipid-transporting ATPase C887.12 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN SPBC887.12 PE 3 SV 1
blastp_uniprot_sprot sp|Q9Y2Q0|AT8A1_HUMAN 96 1180 + 1085 Gaps:61 91.07 1164 38.96 0.0 Probable phospholipid-transporting ATPase IA OS Homo sapiens GN ATP8A1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9NTI2|AT8A2_HUMAN 120 1135 + 1016 Gaps:56 85.89 1148 41.28 0.0 Probable phospholipid-transporting ATPase IB OS Homo sapiens GN ATP8A2 PE 1 SV 2
blastp_uniprot_sprot sp|P70704|AT8A1_MOUSE 96 1174 + 1079 Gaps:76 90.43 1149 39.56 0.0 Probable phospholipid-transporting ATPase IA OS Mus musculus GN Atp8a1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9LK90|ALA8_ARATH 120 1218 + 1099 Gaps:82 94.95 1189 38.44 0.0 Putative phospholipid-transporting ATPase 8 OS Arabidopsis thaliana GN ALA8 PE 3 SV 1
blastp_uniprot_sprot sp|Q29449|AT8A1_BOVIN 96 1180 + 1085 Gaps:76 90.95 1149 39.52 0.0 Probable phospholipid-transporting ATPase IA OS Bos taurus GN ATP8A1 PE 1 SV 2
blastp_uniprot_sprot sp|P98200|AT8A2_MOUSE 120 1131 + 1012 Gaps:52 85.54 1148 40.63 0.0 Probable phospholipid-transporting ATPase IB OS Mus musculus GN Atp8a2 PE 2 SV 1
blastp_uniprot_sprot sp|Q8TF62|AT8B4_HUMAN 110 1182 + 1073 Gaps:73 91.11 1192 37.75 0.0 Probable phospholipid-transporting ATPase IM OS Homo sapiens GN ATP8B4 PE 2 SV 3
blastp_uniprot_sprot sp|P39524|ATC3_YEAST 119 1216 + 1098 Gaps:90 79.70 1355 38.70 0.0 Probable phospholipid-transporting ATPase DRS2 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN DRS2 PE 1 SV 2
rpsblast_cdd gnl|CDD|178732 43 1222 + 1180 Gaps:14 100.00 1178 82.26 0.0 PLN03190 PLN03190 aminophospholipid translocase Provisional.
rpsblast_cdd gnl|CDD|200120 137 1196 + 1060 Gaps:43 100.00 1057 47.49 0.0 TIGR01652 ATPase-Plipid phospholipid-translocating P-type ATPase flippase. This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.
rpsblast_cdd gnl|CDD|30822 140 1188 + 1049 Gaps:235 93.78 917 27.21 1e-114 COG0474 MgtA Cation transport ATPase [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|211660 189 1009 + 821 Gaps:154 97.16 528 30.02 2e-51 TIGR01494 ATPase_P-type ATPase P-type (transporting) HAD superfamily subfamily IC. The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway however in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497 IB (heavy metals) TIGR01525 IIA1 (SERCA-type Ca++) TIGR01116 IIA2 (PMR1-type Ca++) TIGR01522 IIB (PMCA-type Ca++) TIGR01517 IIC (Na+/K+ H+/K+ antiporters) TIGR01106 IID (fungal-type Na+ and K+) TIGR01523 IIIA (H+) TIGR01647 IIIB (Mg++) TIGR01524 IV (phospholipid flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493 TIGR01509 TIGR01549 TIGR01544 and TIGR01545). Based on these classifications the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.
rpsblast_cdd gnl|CDD|162469 499 998 + 500 Gaps:96 41.75 1054 26.36 4e-23 TIGR01657 P-ATPase-V P-type ATPase of unknown pump specificity (type V). These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.
rpsblast_cdd gnl|CDD|200073 490 983 + 494 Gaps:121 45.91 917 31.12 2e-17 TIGR01116 ATPase-IIA1_Ca sarco/endoplasmic reticulum calcium-translocating P-type ATPase. This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice at least there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types SERCA and PMR1 the latter of which is modelled by TIGR01522.
rpsblast_cdd gnl|CDD|188151 442 869 + 428 Gaps:119 37.39 944 27.20 8e-15 TIGR01517 ATPase-IIB_Ca plasma-membrane calcium-translocating P-type ATPase. This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes out of the cell. In some organisms this type of pump may also be found in vacuolar membranes. In humans and mice at least there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly there are no human diseases linked to PMCA defects although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are modelled by two corresponding families (TIGR01116 and TIGR01522). This model is well separated from those.
rpsblast_cdd gnl|CDD|201018 193 475 + 283 Gaps:88 94.14 222 20.57 6e-07 pfam00122 E1-E2_ATPase E1-E2 ATPase.
rpsblast_kog gnl|CDD|35427 121 1215 + 1095 Gaps:35 94.87 1151 43.13 0.0 KOG0206 KOG0206 KOG0206 P-type ATPase [General function prediction only].
rpsblast_kog gnl|CDD|35431 137 1188 + 1052 Gaps:99 91.82 1051 33.06 1e-148 KOG0210 KOG0210 KOG0210 P-type ATPase [Inorganic ion transport and metabolism].

51 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 1 163 163 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 597 615 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Gene3D 892 977 86 G3DSA:3.40.50.1000 none none IPR023214
Gene3D 771 827 57 G3DSA:3.40.50.1000 none none IPR023214
SUPERFAMILY 220 291 72 SSF81653 none none none
SUPERFAMILY 324 361 38 SSF81653 none none none
SUPERFAMILY 366 499 134 SSF81665 none none none
SUPERFAMILY 970 1187 218 SSF81665 none none none
SUPERFAMILY 139 224 86 SSF81665 none none none
Phobius 1119 1124 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
TIGRFAM 137 1196 1060 TIGR01652 none ATPase-Plipid: phospholipid-translocating P-type ATPase, flippase IPR006539
Phobius 460 577 118 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 985 1010 26 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Pfam 504 932 429 PF12710 none haloacid dehalogenase-like hydrolase none
Phobius 1087 1097 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 207 380 174 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 59 1205 1147 PTHR24092 none none IPR006539
Phobius 438 459 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
TIGRFAM 892 1007 116 TIGR01494 none ATPase_P-type: HAD ATPase, P-type, family IC IPR001757
TIGRFAM 435 526 92 TIGR01494 none ATPase_P-type: HAD ATPase, P-type, family IC IPR001757
Phobius 381 406 26 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
SUPERFAMILY 511 546 36 SSF81660 none none IPR023299
SUPERFAMILY 577 775 199 SSF81660 none none IPR023299
Phobius 1098 1118 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 578 596 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
SUPERFAMILY 877 976 100 SSF56784 none none IPR023214
SUPERFAMILY 704 810 107 SSF56784 none none IPR023214
SUPERFAMILY 500 516 17 SSF56784 none none IPR023214
Phobius 640 984 345 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Gene3D 164 293 130 G3DSA:2.70.150.10 none none IPR008250

11 Localization

Analysis Start End Length
TMHMM 1158 1179 21
TMHMM 438 460 22
TMHMM 383 405 22
TMHMM 984 1006 22
TMHMM 180 202 22
TMHMM 578 597 19
TMHMM 1062 1084 22
TMHMM 1126 1148 22
TMHMM 1099 1121 22
TMHMM 617 639 22
TMHMM 1016 1033 17

6 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Bourran2_2015_nP_3P Qrob_Chr12 12 v_10140_295 v_838_303 16 14,69 18,01 lod 5.1 13.7
Bourran1_2004_QTL4_peak_Bud_burst_3P Qrob_Chr04 4 s_1AHUWN_1101 s_1BRNG7_1618 30,55 0 47,55 lod 2,8 7,4
Bourran2_2002_QTL10_peak_Bud_burst_A4 Qrob_Chr04 4 s_1B59MJ_737 s_1BGLSD_999 15,86 0 41,66 lod 2,8 4
Bourran1_2000_QTL3_peak_Bud_burst_3P Qrob_Chr04 4 s_1A6DJQ_418 s_1A1PEC_1268 23,09 9,09 44,09 lod 2,3 6,8
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL7_d13Cf Qrob_Chr04 4 s_1B91MJ_705 s_1AHIKX_640 33.92 12,11 48,31 lod 6.1865 0.023

0 Targeting