Protein : Qrob_P0086280.2 Q. robur
Protein Identifier  ? Qrob_P0086280.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=7) KOG1052//KOG1053//KOG1054//KOG1056//KOG4440 - Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // Glutamate-gated NMDA-type ion channel receptor subunit GRIN2A and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // Glutamate-gated AMPA-type ion channel receptor subunit GluR2 and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits G-protein coupled receptor superfamily [Inorganic ion transport and metabolism Signal transduction mechanisms]. // NMDA selective glutamate-gated ion channel receptor subunit GRIN1 [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. Gene Prediction Quality  validated
Protein length 

Sequence

Length: 692  
Kegg Orthology  K05387
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0004970 ionotropic glutamate receptor activity Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.

39 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103324853 14 667 + 654 Gaps:22 72.05 916 55.61 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|pvu:PHAVU_003G057300g 15 667 + 653 Gaps:30 73.85 895 53.10 0.0 hypothetical protein
blastp_kegg lcl|pmum:103324849 14 666 + 653 Gaps:25 71.58 922 52.42 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|gmx:100780320 15 667 + 653 Gaps:32 73.53 899 52.19 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|rcu:RCOM_1012900 14 667 + 654 Gaps:31 78.65 843 53.09 0.0 glutamate receptor 2 plant putative
blastp_kegg lcl|tcc:TCM_029763 13 667 + 655 Gaps:41 72.25 919 54.67 0.0 Glutamate-gated kainate-type ion channel receptor subunit GluR5 putative
blastp_kegg lcl|gmx:100818619 16 667 + 652 Gaps:34 70.50 939 51.21 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|pvu:PHAVU_006G179300g 15 667 + 653 Gaps:30 70.81 942 49.93 0.0 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10014227mg 13 670 + 658 Gaps:40 93.79 725 51.76 0.0 hypothetical protein
blastp_kegg lcl|pper:PRUPE_ppa001159mg 14 667 + 654 Gaps:45 71.33 893 55.57 0.0 hypothetical protein
blastp_pdb 3kg2_D 381 580 + 200 Gaps:28 27.22 823 24.11 5e-13 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_C 381 580 + 200 Gaps:28 27.22 823 24.11 5e-13 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_B 381 580 + 200 Gaps:28 27.22 823 24.11 5e-13 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_A 381 580 + 200 Gaps:28 27.22 823 24.11 5e-13 mol:protein length:823 Glutamate receptor 2
blastp_uniprot_sprot sp|Q8LGN0|GLR27_ARATH 14 667 + 654 Gaps:64 70.80 952 34.12 1e-110 Glutamate receptor 2.7 OS Arabidopsis thaliana GN GLR2.7 PE 2 SV 3
blastp_uniprot_sprot sp|Q9LFN8|GLR26_ARATH 18 666 + 649 Gaps:82 70.63 967 33.38 6e-105 Glutamate receptor 2.6 OS Arabidopsis thaliana GN GLR2.6 PE 2 SV 2
blastp_uniprot_sprot sp|Q9SHV2|GLR23_ARATH 13 670 + 658 Gaps:86 76.87 895 34.45 1e-103 Glutamate receptor 2.3 OS Arabidopsis thaliana GN GLR2.3 PE 2 SV 1
blastp_uniprot_sprot sp|O81078|GLR29_ARATH 14 666 + 653 Gaps:74 71.17 940 35.87 6e-103 Glutamate receptor 2.9 OS Arabidopsis thaliana GN GLR2.9 PE 2 SV 1
blastp_uniprot_sprot sp|Q9LFN5|GLR25_ARATH 18 666 + 649 Gaps:77 73.86 918 33.04 9e-103 Glutamate receptor 2.5 OS Arabidopsis thaliana GN GLR2.5 PE 2 SV 2
blastp_uniprot_sprot sp|Q9SHV1|GLR22_ARATH 14 667 + 654 Gaps:77 74.24 920 33.24 7e-101 Glutamate receptor 2.2 OS Arabidopsis thaliana GN GLR2.2 PE 2 SV 1
blastp_uniprot_sprot sp|O04660|GLR21_ARATH 14 667 + 654 Gaps:74 75.03 901 32.69 7e-97 Glutamate receptor 2.1 OS Arabidopsis thaliana GN GLR2.1 PE 2 SV 2
blastp_uniprot_sprot sp|O81776|GLR24_ARATH 17 667 + 651 Gaps:82 74.22 896 34.74 4e-96 Glutamate receptor 2.4 OS Arabidopsis thaliana GN GLR2.4 PE 2 SV 2
blastp_uniprot_sprot sp|Q9C5V5|GLR28_ARATH 14 666 + 653 Gaps:71 71.17 947 33.68 2e-95 Glutamate receptor 2.8 OS Arabidopsis thaliana GN GLR2.8 PE 2 SV 2
blastp_uniprot_sprot sp|Q7XJL2|GLR31_ARATH 21 666 + 646 Gaps:76 74.05 921 30.65 1e-90 Glutamate receptor 3.1 OS Arabidopsis thaliana GN GLR3.1 PE 2 SV 2
rpsblast_cdd gnl|CDD|107361 12 327 + 316 Gaps:41 83.14 350 34.71 5e-54 cd06366 PBP1_GABAb_receptor Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and like glutamate and other transmitters acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha_i proteins and activation causes a decrease in calcium an increase in potassium membrane conductance and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release for example.
rpsblast_cdd gnl|CDD|153138 6 260 + 255 Gaps:31 65.52 348 26.32 1e-26 cd06350 PBP1_GPCR_family_C_like Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further devided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP which is a bacterial periplasmic protein (PBP) as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA AMPA and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.
rpsblast_cdd gnl|CDD|201592 14 295 + 282 Gaps:25 83.09 343 26.67 6e-26 pfam01094 ANF_receptor Receptor family ligand binding region. This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.
rpsblast_cdd gnl|CDD|189368 481 646 + 166 Gaps:23 68.28 268 24.04 1e-24 pfam00060 Lig_chan Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.
rpsblast_cdd gnl|CDD|153137 1 219 + 219 Gaps:24 69.46 298 25.60 7e-19 cd06269 PBP1_glutamate_receptors_like Family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors. This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors all of which are structurally similar and related to the periplasmic-binding fold type I family. The family C GPCRs consist of metabotropic glutamate receptor (mGluR) receptors a calcium-sensing receptor (CaSR) gamma-aminobutyric receptors (GABAb) the promiscuous L-alpha-amino acid receptor GPR6A families of taste and pheromone receptors and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids ions and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors AMPA receptors and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B) the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E GC-F) and olfactory receptors (GC-D and GC-G).
rpsblast_cdd gnl|CDD|107261 7 260 + 254 Gaps:36 79.60 299 21.01 1e-13 cd04509 PBP1_ABC_transporter_GCPR_C_like Family C of G-protein coupled receptors and their close homologs the type I periplasmic-binding proteins of ATP-binding cassette transporter-like systems. This CD includes members of the family C of G-protein coupled receptors and their close homologs the type I periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor G-protein-coupled receptors metabotropic glutamate GABA-B calcium sensing phermone receptors and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels iGluR can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate) AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4- isoxazolepropionic acid) and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine-binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem a LIVBP-like domain that constitutes the N terminus - which is included in this CD - followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type II periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.

23 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 385 649 265 PF00497 none Bacterial extracellular solute-binding proteins, family 3 none
Gene3D 477 613 137 G3DSA:1.10.287.70 none none none
Phobius 1 480 480 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 541 559 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Pfam 12 296 285 PF01094 none Receptor family ligand binding region IPR001828
Pfam 481 610 130 PF00060 none Ligand-gated ion channel IPR001320
Phobius 530 540 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 4 667 664 PTHR18966 none none none
Gene3D 79 232 154 G3DSA:3.40.50.2300 none none none
Phobius 481 499 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 684 691 8 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Gene3D 340 476 137 G3DSA:3.40.190.10 none none none
PANTHER 4 667 664 PTHR18966:SF6 none none none
Gene3D 14 75 62 G3DSA:3.40.50.2300 none none none
Gene3D 233 296 64 G3DSA:3.40.50.2300 none none none
Phobius 560 660 101 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
SUPERFAMILY 346 483 138 SSF53850 none none none
SUPERFAMILY 586 665 80 SSF53850 none none none
SMART 360 682 323 SM00079 none Eukaryotic homologues of bacterial periplasmic substrate binding proteins. IPR001320
Phobius 500 510 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 511 529 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
SUPERFAMILY 4 350 347 SSF53822 none none IPR028082
Phobius 661 683 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none

4 Localization

Analysis Start End Length
TMHMM 514 531 17
TMHMM 480 499 19
TMHMM 538 560 22
TMHMM 661 683 22

12 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7
Bourran2_2004_QTL9_peak_Bud_burst_3P Qrob_Chr02 2 s_1C34E9_788 v_12238_322 50 25 75 lod 4,4 10,1
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL2_d13Cf Qrob_Chr02 2 s_1AQA4Z_1644 s_1AK5QX_947 53.67 14,01 79,68 lod 5.6594 0.03
Bourran1_2004_QTL2_peak_Bud_burst_3P Qrob_Chr02 2 s_1AW12F_382 s_1A77MR_223 42 6 64 lod 3,6 9,6
Bourran_2000_2002_QTL2_Delta.F Qrob_Chr02 2 s_1CSO13_1244 s_1AVEUF_1540 55.44 46,71 63,68 lod 7.3232 0.058
Bourran2_2002_QTL7_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 29 52 lod 8,1 16
Bourran2_2002_QTL9_peak_Bud_burst_A4 Qrob_Chr02 2 s_1BFNDA_375 s_1A3VA1_2139 32,5 17 62 lod 3,1 4,2
Bourran2_2003_QTL8_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 0 72 lod 4,4 9,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nP_A4 Qrob_Chr02 2 s_1A0FUE_1868 s_1A1UAI_500 20,64 20,47 21,36 lod 5.8 10.9
Bourran2_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 24,87 24,63 26,18 lod 3.8 7
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL6_d13Cf Qrob_Chr02 2 s_1AEP21_172 v_6048_204 46.33 22,5 65,23 lod 4.972 0.03

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 15   Secretory pathway 5 0.799 0.032 NON-PLANT 15