Protein : Qrob_P0041480.2 Q. robur
Protein Identifier  ? Qrob_P0041480.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) PTHR13620//PTHR13620:SF3 - 3-5 EXONUCLEASE // SUBFAMILY NOT NAMED Code Enzyme  EC:3.6.4.12
Gene Prediction Quality  validated Protein length 

Sequence

Length: 65  
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0006139 nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0008408 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

12 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa023705mg 2 63 + 62 Gaps:1 25.82 244 63.49 2e-17 hypothetical protein
blastp_kegg lcl|mdm:103443411 2 62 + 61 Gaps:1 19.20 323 62.90 8e-17 Werner Syndrome-like exonuclease
blastp_kegg lcl|pda:103720152 2 51 + 50 none 15.92 314 70.00 1e-16 Werner Syndrome-like exonuclease
blastp_kegg lcl|fve:101311662 2 48 + 47 none 15.77 298 74.47 1e-16 Werner Syndrome-like exonuclease-like
blastp_kegg lcl|pvu:PHAVU_001G266900g 2 64 + 63 Gaps:1 21.16 293 56.45 1e-16 hypothetical protein
blastp_kegg lcl|cam:101490726 2 61 + 60 Gaps:1 19.60 301 61.02 1e-16 Werner Syndrome-like exonuclease-like
blastp_kegg lcl|mtr:MTR_3g084280 2 51 + 50 none 16.08 311 66.00 2e-16 Werner syndrome ATP-dependent helicase
blastp_kegg lcl|pmum:103322662 2 62 + 61 Gaps:1 19.38 320 61.29 2e-16 Werner Syndrome-like exonuclease
blastp_kegg lcl|rcu:RCOM_0523740 2 61 + 60 none 40.27 149 63.33 3e-16 3'-5' exonuclease putative
blastp_kegg lcl|cmo:103483463 2 51 + 50 none 15.92 314 66.00 7e-16 Werner Syndrome-like exonuclease
blastp_uniprot_sprot sp|Q84LH3|WEX_ARATH 2 46 + 45 none 15.62 288 64.44 7e-14 Werner Syndrome-like exonuclease OS Arabidopsis thaliana GN WEX PE 1 SV 1
rpsblast_cdd gnl|CDD|176653 1 42 + 42 none 24.71 170 54.76 4e-09 cd06141 WRN_exo DEDDy 3'-5' exonuclease domain of WRN and similar proteins. WRN is a unique RecQ DNA helicase exhibiting an exonuclease activity. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Mutations in the WRN gene cause Werner syndrome an autosomal recessive disorder associated with premature aging and increased susceptibility to cancer and type II diabetes. WRN interacts with key proteins involved in DNA replication recombination and repair. It is believed to maintain genomic stability and life span by participating in DNA processes. WRN is stimulated by Ku70/80 an important regulator of genomic stability.

5 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 11 42 32 PF01612 none 3'-5' exonuclease IPR002562
SUPERFAMILY 2 42 41 SSF53098 none none IPR012337
PANTHER 2 45 44 PTHR13620 none none none
PANTHER 2 45 44 PTHR13620:SF3 none none none
Gene3D 2 41 40 G3DSA:3.30.420.10 none none IPR012337

0 Localization

0 Qtllist

0 Targeting